Fig. 4.

Dopaminergic neurotransmission is altered in Tg mice. (a) Autoradiography of D1-like and D2-like receptors and DAT binding on brain sections. For quantification see SI Table 2. (Scale bar: 4 mm.) (b) c-fos induction in the striatum in response to amphetamine is significantly higher in Tg mice (P = 0.04). (c) c-fos induction in the striatum in response to DHX is significantly higher in Tg mice (P = 0.01). (d) Representative traces of evoked dopamine release in nucleus accumbens in response to a 1-mA current pulse to the medial forebrain bundle. (e) Amplitude of evoked dopamine release is enhanced in Tg compared with WT mice (n = 10; 0.1 mA, P = 0.044; 1 mA, P = 0.007). Error bars represent SEM.