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. 1993 Feb;37(2):357–359. doi: 10.1128/aac.37.2.357

Acyclovir susceptibilities of herpes simplex virus strains isolated from solid organ transplant recipients after acyclovir or ganciclovir prophylaxis.

G Boivin 1, A Erice 1, D D Crane 1, D L Dunn 1, H H Balfour Jr 1
PMCID: PMC187669  PMID: 8383946

Abstract

We determined the acyclovir (ACV) susceptibilities of herpes simplex virus (HSV) isolates (n = 18) recovered from solid organ transplant patients after antiviral prophylaxis with ACV or ganciclovir. All isolates tested were susceptible to ACV (50% inhibitory concentration, < 1 microM). A clinical review of patients with HSV disease showed that all improved with specific anti-HSV therapy, and no recurrences were reported.

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Selected References

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  1. Bailey T. C., Trulock E. P., Ettinger N. A., Storch G. A., Cooper J. D., Powderly W. G. Failure of prophylactic ganciclovir to prevent cytomegalovirus disease in recipients of lung transplants. J Infect Dis. 1992 Mar;165(3):548–552. doi: 10.1093/infdis/165.3.548. [DOI] [PubMed] [Google Scholar]
  2. Balfour H. H., Jr, Chace B. A., Stapleton J. T., Simmons R. L., Fryd D. S. A randomized, placebo-controlled trial of oral acyclovir for the prevention of cytomegalovirus disease in recipients of renal allografts. N Engl J Med. 1989 May 25;320(21):1381–1387. doi: 10.1056/NEJM198905253202105. [DOI] [PubMed] [Google Scholar]
  3. Chatis P. A., Crumpacker C. S. Analysis of the thymidine kinase gene from clinically isolated acyclovir-resistant herpes simplex viruses. Virology. 1991 Feb;180(2):793–797. doi: 10.1016/0042-6822(91)90093-q. [DOI] [PubMed] [Google Scholar]
  4. Collins P., Larder B. A., Oliver N. M., Kemp S., Smith I. W., Darby G. Characterization of a DNA polymerase mutant of herpes simplex virus from a severely immunocompromised patient receiving acyclovir. J Gen Virol. 1989 Feb;70(Pt 2):375–382. doi: 10.1099/0022-1317-70-2-375. [DOI] [PubMed] [Google Scholar]
  5. Collins P., Oliver N. M. Sensitivity monitoring of herpes simplex virus isolates from patients receiving acyclovir. J Antimicrob Chemother. 1986 Oct;18 (Suppl B):103–112. doi: 10.1093/jac/18.supplement_b.103. [DOI] [PubMed] [Google Scholar]
  6. Englund J. A., Zimmerman M. E., Swierkosz E. M., Goodman J. L., Scholl D. R., Balfour H. H., Jr Herpes simplex virus resistant to acyclovir. A study in a tertiary care center. Ann Intern Med. 1990 Mar 15;112(6):416–422. doi: 10.7326/0003-4819-76-3-112-6-416. [DOI] [PubMed] [Google Scholar]
  7. Erlich K. S., Mills J., Chatis P., Mertz G. J., Busch D. F., Follansbee S. E., Grant R. M., Crumpacker C. S. Acyclovir-resistant herpes simplex virus infections in patients with the acquired immunodeficiency syndrome. N Engl J Med. 1989 Feb 2;320(5):293–296. doi: 10.1056/NEJM198902023200506. [DOI] [PubMed] [Google Scholar]
  8. Gold D., Corey L. Acyclovir prophylaxis for herpes simplex virus infection. Antimicrob Agents Chemother. 1987 Mar;31(3):361–367. doi: 10.1128/aac.31.3.361. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hill E. L., Hunter G. A., Ellis M. N. In vitro and in vivo characterization of herpes simplex virus clinical isolates recovered from patients infected with human immunodeficiency virus. Antimicrob Agents Chemother. 1991 Nov;35(11):2322–2328. doi: 10.1128/aac.35.11.2322. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Ljungman P., Ellis M. N., Hackman R. C., Shepp D. H., Meyers J. D. Acyclovir-resistant herpes simplex virus causing pneumonia after marrow transplantation. J Infect Dis. 1990 Jul;162(1):244–248. doi: 10.1093/infdis/162.1.244. [DOI] [PubMed] [Google Scholar]
  11. Merigan T. C., Renlund D. G., Keay S., Bristow M. R., Starnes V., O'Connell J. B., Resta S., Dunn D., Gamberg P., Ratkovec R. M. A controlled trial of ganciclovir to prevent cytomegalovirus disease after heart transplantation. N Engl J Med. 1992 Apr 30;326(18):1182–1186. doi: 10.1056/NEJM199204303261803. [DOI] [PubMed] [Google Scholar]
  12. Meyers J. D., Reed E. C., Shepp D. H., Thornquist M., Dandliker P. S., Vicary C. A., Flournoy N., Kirk L. E., Kersey J. H., Thomas E. D. Acyclovir for prevention of cytomegalovirus infection and disease after allogeneic marrow transplantation. N Engl J Med. 1988 Jan 14;318(2):70–75. doi: 10.1056/NEJM198801143180202. [DOI] [PubMed] [Google Scholar]
  13. Pettersson E., Hovi T., Ahonen J., Fiddian A. P., Salmela K., Höckerstedt K., Eklund B., von Willebrand E., Häyry P. Prophylactic oral acyclovir after renal transplantation. Transplantation. 1985 Mar;39(3):279–281. doi: 10.1097/00007890-198503000-00014. [DOI] [PubMed] [Google Scholar]
  14. Sacks S. L., Wanklin R. J., Reece D. E., Hicks K. A., Tyler K. L., Coen D. M. Progressive esophagitis from acyclovir-resistant herpes simplex. Clinical roles for DNA polymerase mutants and viral heterogeneity? Ann Intern Med. 1989 Dec 1;111(11):893–899. doi: 10.7326/0003-4819-111-11-893. [DOI] [PubMed] [Google Scholar]
  15. Safrin S., Assaykeen T., Follansbee S., Mills J. Foscarnet therapy for acyclovir-resistant mucocutaneous herpes simplex virus infection in 26 AIDS patients: preliminary data. J Infect Dis. 1990 Jun;161(6):1078–1084. doi: 10.1093/infdis/161.6.1078. [DOI] [PubMed] [Google Scholar]
  16. Seale L., Jones C. J., Kathpalia S., Jackson G. G., Mozes M., Maddux M. S., Packham D. Prevention of herpesvirus infections in renal allograft recipients by low-dose oral acyclovir. JAMA. 1985 Dec 27;254(24):3435–3438. [PubMed] [Google Scholar]
  17. Shepp D. H., Dandliker P. S., Flournoy N., Meyers J. D. Once-daily intravenous acyclovir for prophylaxis of herpes simplex virus reactivation after marrow transplantation. J Antimicrob Chemother. 1985 Sep;16(3):389–395. doi: 10.1093/jac/16.3.389. [DOI] [PubMed] [Google Scholar]
  18. Stoffel M., Squifflet J. P., Pirson Y., Lamy M., Alexandre G. P. Effectiveness of oral acyclovir prophylaxis in renal transplant recipients. Transplant Proc. 1987 Feb;19(1 Pt 3):2190–2193. [PubMed] [Google Scholar]
  19. Swierkosz E. M., Scholl D. R., Brown J. L., Jollick J. D., Gleaves C. A. Improved DNA hybridization method for detection of acyclovir-resistant herpes simplex virus. Antimicrob Agents Chemother. 1987 Oct;31(10):1465–1469. doi: 10.1128/aac.31.10.1465. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Wade J. C., Newton B., Flournoy N., Meyers J. D. Oral acyclovir for prevention of herpes simplex virus reactivation after marrow transplantation. Ann Intern Med. 1984 Jun;100(6):823–828. doi: 10.7326/0003-4819-100-6-823. [DOI] [PubMed] [Google Scholar]

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