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. Author manuscript; available in PMC: 2008 Apr 1.
Published in final edited form as: Neurobiol Dis. 2006 Dec 20;26(1):134–145. doi: 10.1016/j.nbd.2006.12.008

Fig. 5.

Fig. 5

BACE1 null mutation prevents gliosis in 5XFAD transgenic mice. Sagittal sections of cerebral cortex from wild-type control (A), BACE1−/− (B), 5XFAD (C) and BACE1−/−·5XFAD (D) mice at 18 months of age were immunostained for astrocyte marker GFAP and counterstained with hematoxylin. Note that 5XFAD cortex shows extensive astrogliosis, while BACE1−/−·5XFAD brain has control levels of astrocytes. Scale bar = 200 μm.