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. Author manuscript; available in PMC: 2008 Apr 1.
Published in final edited form as: Neurobiol Dis. 2006 Dec 20;26(1):134–145. doi: 10.1016/j.nbd.2006.12.008

Fig. 6.

Fig. 6

BACE1 null mutation prevents memory deficits in 5XFAD transgenic mice. (A) Spatial working memory of mice at 15–18 months of age was tested by spontaneous alternation performance in the Y-maze. BACE1−/−·5XFAD mice are rescued completely back to wild-type levels of alternation in the Y-maze. Note also that both BACE1−/− mice and 5XFAD mice show significantly lower levels of alternation performance as compared to wild-type control and BACE1−/−·5XFAD mice, although the deficit for 5XFAD tends to be more severe. (B) Total number of arm entries indicates that BACE1−/− mice show significantly higher levels of exploratory activity in the Y-maze as compared to wild-type control mice. Data are presented as the mean ± SEM of 7–14 animals. **P < 0.01 (vs. wild-type controls), #P < 0.05, ##P < 0.01 (vs. BACE1−/−·5XFAD).