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. 2000 May 23;97(12):6868–6873. doi: 10.1073/pnas.120172697

Figure 2.

Figure 2

Effect of ALS genotype on the expression of the ALS gene. (Left) Total RNA was isolated from the liver and kidney of 10-week-old mice. Aliquots (15 μg) from wild-type (+/+, lanes 1 and 2), heterozygous (+/−, lanes 3 and 4), and null (−/−, lanes 5 and 6) ALS mice were analyzed by Northern blotting using the coding ALS probe that detects a unique mRNA of ≈2.2 kb. The signal obtained with the 18S riboprobe is shown for both tissues. (Right) For each tissue, means ± SE of ALS hybridization signals are shown (six animals per genotype). Means with different letters differ at P < 0.05 using GLM followed by Fisher's protected least significant differences analysis.