Figure 4. .

Reduced median network of HVS-I sequences of haplogroup E in the region 16050–16400. The circles represent mtDNA HVS-I sequence types, shaded according to region and with an area proportional to their frequency in each region. Links are labeled with the nucleotide position of mutations; letters following positions indicate transversions, and the others are transitions. Mutations that have occurred more than once in the tree are underlined. Coding-region positions that were sequenced are indicated in italics. Subclades are labeled, and the M9 ancestor is indicated (arrow).