Table 2.
Hamsters Group no. | West Nile immunogens | Hamsters # Survivors/totala | Hamsters % Survivala |
---|---|---|---|
1 | adjuvant/mock antigenb | 7/15 | 47 |
2 | 1 μg NS1 | 13/15c | 87 |
3 | 1 μg 80E | 15/15d | 100 |
4 | 1 μg 80E+1 μg NS1 | 15/15d | 100 |
5 | 10 μg 80E | 15/15d | 100 |
6 | 10 μg 80E+1 μg NS1 | 15/15d | 100 |
30 days post challenge.
12 μg of ISCOMATRIX® adjuvant per dose present in all groups; “mock antigen” = equivalent of 10 μg of 80E purified by IAC from an induced “mock” 80E transformed S2 cell line, i.e., S2 cells transformed with plasmid DNA without the prM80E insert [5].
p value = 0.022 relative to group 1 (Fisher exact probability test).
p value = 0.0011 relative to group 1 (Fisher exact probability test).