Table 2.

Protective efficacy of a West Nile candidate vaccine in golden hamsters based on challenge with wild type West Nile virus

Hamsters Group no.	West Nile immunogens	Hamsters # Survivors/totala	Hamsters % Survivala
1	adjuvant/mock antigenb	7/15	47
2	1 μg NS1	13/15c	87
3	1 μg 80E	15/15d	100
4	1 μg 80E+1 μg NS1	15/15d	100
5	10 μg 80E	15/15d	100
6	10 μg 80E+1 μg NS1	15/15d	100

^a30 days post challenge.

^b12 μg of ISCOMATRIX^® adjuvant per dose present in all groups; “mock antigen” = equivalent of 10 μg of 80E purified by IAC from an induced “mock” 80E transformed S2 cell line, i.e., S2 cells transformed with plasmid DNA without the prM80E insert [5].

^cp value = 0.022 relative to group 1 (Fisher exact probability test).

^dp value = 0.0011 relative to group 1 (Fisher exact probability test).