Table 4.
Summary of West Nile post booster vaccination antibody titers in hamsters prior to challenge with wild type West Nile virus
| Group # | Vaccine | Time of Assay Post Booster Vaccination | HI Titera | CF Titera | PRNT90 Titera |
|---|---|---|---|---|---|
| 1 | Adjuvant Control | 2 weeks | <20 | <10 | <10 |
| 2 | 1 μg 80E | 2 weeks | 113 (87–147) | 57 (44–73) | 84 (37–183) |
| 3 | Adjuvant Control | 6 months | <20 | <10 | <20 |
| 4 | 1 μg 80E | 6 months | 133 (98–181) | 58 (38–89) | 211 (154–290) |
| 5 | 1 μg 80E + 1 μg NS1 | 6 months | 121 (91–161) | 101 (67–151) | 254 (186–348) |
| 6 | Adjuvant Control | 12 months | <10 | <10 | <20 |
| 7 | 1 μg 80E | 12 months | 38 (19–76) | 10 (7–15) | 266 (159–444) |
| 8 | 1 μg 80E + 1 μg NS1 | 12 months | 26 (14–48) | 10 (6–16) | 390 (230–663) |
a
Geometric mean (GMT) hemagglutination inhibition (HI), complement fixation (CF) and neutralizing antibody (PRNT) titers for individual animals (lower 95% CI of GMT-upper 95% CI of GMT; N=14 for groups 2,8, N=15 all other groups)