. Author manuscript; available in PMC: 2008 Apr 5.

Published in final edited form as: Regul Pept. 2006 Dec 28;140(1-2):12–20. doi: 10.1016/j.regpep.2006.11.020

Table 1.

Effects of Kallikrein Infusion on Cardiac Function 7 Days after MI

Variable	Sham	MI	MI/TK	MI/TK+Icatibant
Infarct Size	0	0.37 ± 0.03	0.19 ± 0.036^*	0.31 ± 0.05
LV Wall Thickness (mm)	3.5 ±10.15	1.3 ± 0.11	2.58 ± 0.27 ^*	1.86 ± 0.32
Heart Rate (bpm)	382.3 ± 16.4	378.7 ± 17.6	368.1 ± 14.1	378.1 ± 13.3
MAP (mmHg)	101.0 ± 5.58	67.7 ± 2.76	85.4 ± 6.04 ^*	67.6 ± 7.53
LVEDP (mmHg)	2.95 ± 0.87	16.27 ± 1.55	7.91 ± 1.02 ^*	13.50 ± 2.02
dP/dt max (mmHg/s)	4163.2 ± 153.9	2196.5 ± 127.4	2842.4 ± 143.3^*	2133.7 ± 104.0
dP/dt min (mmHg/s)	3390.5 ± 139.1	1462.5 ± 121.4	2137.7 ± 154.6^*	1441.2 ± 100.2

Values are mean ± SEM.

P<0.05 vs. MI &MI/TK+Icatibant.

MI: myocardial infarction; MI/TK: MI with tissue kallikrein infusion; MI/TK+Icatibant: MI with tissue kallikrein and icatibant infusion.