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Inhibition of CD26 enzymatic activity accelerates clearance of glucose administered intraperitoneally in GLP-1R−/− mice. (A) Intraperitoneal glucose tolerance test in male GLP-1R−/− mice given vehicle (water) or valine-pyrrolidide at time −30 min and glucose at time 0. (B) Plasma insulin levels 15 min after glucose challenge in the animals shown in A, given vehicle (H2O) or valine-pyrrolidide (V-P), as indicated. n = 8–14. *, P < 0.05; **, P < 0.01.
