Table 2.

Densitometry Analysis of Endoglin and PECAM-1 on Endothelial cells.

Vessel type		Control				Patient H9			Relative endoglin levels (%)
		Endoglin mean density	PECAM-1 mean density	E/P ratio		Endoglin mean density	PECAM-1 mean density	E/P ratio
Lung artery	A	112 ± 1.7	153 ± 1.6	0.73	a	69 ± 1.4	155 ± 1.9	0.45	61 ± 6%
Lung vein	B	145 ± 1.4	142 ± 1.4	1.02	b	30 ± 0.5	95 ± 1.5	0.32	31 ± 5%
Lung capillaries	C	128 ± 1.5	144 ± 2.1	0.89	c	80 ± 1.7	171 ± 2.1	0.47	52 ± 6%
Lung artery		125 ± 2.1	171 ± 2.0	0.73		75 ± 1.7	182 ± 2.2	0.41	57 ± 6%
Lung artery		106 ± 1.8	139 ± 2.1	0.76		58 ± 1.3	163 ± 2.6	0.36	46 ± 7%
Lung vein		133 ± 1.7	126 ± 2.6	1.06		81 ± 1.6	146 ± 2.8	0.55	52 ± 7%
Lung capillaries		113 ± 1.9	107 ± 1.8	1.06		69 ± 1.1	138 ± 1.5	0.50	47 ± 6%
Spinal cord artery	D	123 ± 1.5	179 ± 2.2	0.69	d	51 ± 0.8	121 ± 1.7	0.42	61 ± 5%
Spinal cord artery	E	119 ± 1.2	121 ± 1.6	0.98	e	59 ± 0.8	87 ± 1.1	0.68	69 ± 5%
Spinal cord vein	F	116 ± 1.4	141 ± 1.8	0.82	f	61 ± 1.0	109 ± 1.6	0.56	68 ± 6%
Spinal cord vein	G	137 ± 1.5	147 ± 1.7	0.93	g	42 ± 0.8	103 ± 1.2	0.41	44 ± 5%
CAVM feeder artery		N.A.	N.A.	N.A.		97 ± 2.4	195 ± 1.4	0.50	N.A.
CAVM venous pouch		N.A.	N.A.	N.A.		27 ± 0.8	46 ± 1.5	0.58	N.A.

The mean density values were evaluated for selected vessels indicated by corresponding letters in Figures 5 to 7 ▶ ▶ ▶ , as well as additional ones in adjacent tissues, and are expressed as mean ± SEM of 300 measurements per vessel. The relative endoglin levels (%) are estimated as endoglin mean density/PECAM-1 mean density of patient H9 versus the endoglin level of a newborn control. E/P, Endoglin/PECAM-1 ratio; N.A., not applicable.