Table 2.
Full-Length HGF Receptor Expression in Human Soft Tissue and Bone Tumors
| Tumors (n) | Immunohistochemistry | Western blot | Relative expression* | ||
|---|---|---|---|---|---|
| + | ++ | +++ | |||
| Benign soft tissue tumors | |||||
| Benign fibrous histiocytoma (6) | 5 /6 | ND | |||
| Desmoid (6) | 2 /6 | 1 /5 | 1 | 0 | 0 |
| Lipoma (3) | 0 /1 | 0 /2 | 0 | 0 | 0 |
| Schwannoma (3) | 2 /3 | 3 /3 | 2 | 0 | 1 |
| Neurofibroma (2) | 0 /2 | 0 /2 | 0 | 0 | 0 |
| Hibernoma (2) | 0 /1 | 0 /2 | 0 | 0 | 0 |
| Hemangioma (2) | 0 /2 | 0 /2 | 0 | 0 | 0 |
| Fibrous hamartoma of infancy (1) | 1 /1 | 0 /1 | 0 | 0 | 0 |
| Intramuscular myxoma (1) | 0 /1 | 1 /1 | 1 | 0 | 0 |
| Subtotal (26) | 10 /23 (43%) | 5 /18 (28%) | 4 | 0 | 1 |
| Benign bone tumors | |||||
| Giant cell tumor (GCT) of bone (6) | 6 /6 (100%) | 3 /3 (100%) | 3 | 0 | 0 |
| Total benign tumors (32) | 16 /29 (55%) | 8 /21 (38%) | 7 | 0 | 1 |
| Malignant soft tissue tumors | |||||
| Malignant fibrous histiocytoma (MFH) (14) | 7 /8 | 13 /14 | 7 | 3 | 3 |
| Liposarcoma (11) | 8 /9 | 6 /9 | 3 | 3 | 0 |
| Dermatofibrosarcoma protuberans (6) | 2 /6 | 1 /1 | 1 | 0 | 0 |
| Angiosarcoma (5) | 4 /5 | ND | |||
| Leiomyosarcoma (4) | 2 /4 | 1 /1 | 1 | 0 | 0 |
| Extraskeletal myxoid chondrosarcoma (4) | 4 /4 | 1 /1 | 1 | 0 | 0 |
| Clear cell sarcoma (3) | 3 /3 | 1 /1 | 0 | 0 | 1 |
| Epitheloid sarcoma (2) | 2 /2 | ND | |||
| Malignant peripheral nerve sheath tumor (2) | 2 /2 | 2 /2 | 0 | 1 | 1 |
| Fibrosarcoma (1) | 1 /1 | 1 /1 | 1 | 0 | 0 |
| Malignant hemangiopericytoma (1) | 0 /1 | 0 /1 | 0 | 0 | 0 |
| Primitive neuroectodermal tumor (1) | 1 /1 | 1 /1 | 1 | 0 | 0 |
| Extraskeletal osteosarcoma (1) | Not detected | 0 /1 | 0 | 0 | 0 |
| Subtotal (55) | 36 /46 (78%) | 27 /33 (82%) | 15 | 7 | 5 |
| Malignant bone tumors | |||||
| Chondrosarcoma (6) | 5 /5 | 4 /6 | 2 | 1 | 0 |
| Osteosarcoma (5) | 3 /4 | 1 /2 | 1 | 0 | 0 |
| Chordoma (4) | 3 /4 | 3 /3 | 1 | 2 | 0 |
| Subtotal (15) | 11 /13 (85%) | 8 /11 (73%) | 4 | 3 | 0 |
| Total malignant tumors (70) | 47 /59 (80%) | 35 /44 (80%) | 19 | 10 | 5 |
| Total (102) | 63 /88 (72%) | 43 /65 (66%) | 26 | 10 | 6 |
*Relative expression estimated by densitometry in Western blotting: +, mild; ++, moderate; +++, strong. ND, not detected.