Table 1.

Incidence of Tumor Necrosis after rmTNF Administration in Wild-Type and TNFR-Deficient Mice

Mouse strain	Incidence of tumor necrosis
	PBS	rmTNF	P value
C57BL/6	1 /30	38 /43	<10−7
TNFRp55−/−	1 /7	0 /26
TNFRp75−/−	0 /5	9 /15	<0.05

Tumor (wt BFS-1)-bearing C57BL/6 wt or TNFR-deficient mice were treated with rmTNF (5 μg in 100 μl PBS) or PBS (100 μl) i.p., and the incidence of tumor necrosis in histological sections was scored 2 days after treatment. Results are pooled from at least three experiments per group. P values for the comparison of the PBS-treated versus rmTNF-treated groups are given.