Table 2.
Summary of 9p21 Region Alterations in the Plaque and Tumoral Stages of MF
| Cases | Plaque stage | Tumoral stage | |||
|---|---|---|---|---|---|
| Methylation p16INK4a | Allelic loss | Methylation p16INK4a | Allelic loss | Mutation p16INK4a | |
| MF36 | ND | − | − | HD | wt* |
| MF39 | + | − | + | LOH | ND |
| MF113 | ND | LOH | ND | LOH | wt |
| MF90 | ND | − | ND | − | ND |
| MF91 | + | − | + | − | wt |
| MF73 | − | ND | + | − | wt |
| MF78 | − | ND | + | − | wt |
| MF82 | − | − | − | − | wt |
| MF122 | + | − | + | − | wt |
| 3/6 | 1/7 | 5/7 | 3/9 | 0/7 | |
| Total alterations | 4/9 | 7/9 |
HD, homozygous deletion; LOH, loss of heterozygosity; ND, not done; +, positive; −, negative.
*wt due to reactive cells associated with the tumor as it presents HD.