Table 3.
Distribution of K-ras Gene Mutations in Medullary and Nonmedullary Adenocarcinomas of the Pancreas
| GAT (codon 12) | GTT (codon 12) | CGT (codon 12) | GCT (codon 12) | AGT (codon 12) | TTT (codon 12) | GTTTGC (codons 12 and 13) | CTC (codon 13) | CAT (codon 61) | Wild type | |
|---|---|---|---|---|---|---|---|---|---|---|
| Microdissected medullary carcinomas (n = 13) | 2 | 0 | 1 | 0 | 0 | 1* | 0 | 0 | 0 | 9 |
| Xenografted medullary carcinomas (n = 5) | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3 |
| Microdissected non-medullary carcinomas (n = 5) | 4 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Xenografted non-medullary carcinomas (n = 72) | 33 | 22 | 9 | 0 | 1 | 0 | 1† | 1 | 1 | 4 |
| Total (n = 95) | 40 | 22 | 11 | 1 | 1 | 1 | 1 | 1 | 1 | 16 |
*One microdissected medullary carcinoma contained a dinucleotide mutation (GGT to TTT) at codon 12.
†One xenografted nonmedullary carcinoma contained a di-codon mutation of one allele, comprising a GTT mutation in codon 12 and a TGC mutation in codon 13.