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A: Southern blot with a p16/MTS1-exon-2 probe that also recognized p15/INK4b-exon2. PT-LPD 13 showed a pattern similar to that of Jurkat cells, which are known to have homozygous deletion of the p16/MTS1-p15/MTS2 locus. −, 16/INK4a protein is absent; +, p16/INK4a protein is present. B: Methylation-specific PCR. Methylated (M) DNA (*) was detected in PT-LPD 14, from a patient belonging to group 1 (no detection of p16/INK4a protein). U, unmethylated.
