Table 2.
Distribution of HEA-125, EMA, NCAM, and Bcl-2 on Biliary Epithelium in Normal and Diseased Liver Tissue
| HEA 125 | EMA | NCAM | Bcl-2 | |
|---|---|---|---|---|
| Normal liver | ||||
| Ductules | + | + | − | − |
| Ducts | + | + | − | − |
| Parenchymal liver cirrhosis | ||||
| Typical reactive ductules | + | + | − | − |
| Atypical reactive ductules | + | − | ± | ± |
| Ducts | + | + | − | − |
| Primary immune-mediated | ||||
| cholangiopathies | ||||
| Typical reactive ductules | + | + | − | − |
| Atypical reactive ductules | + | − | + | + |
| Ducts | + | + | − | − |
| Congenital cholangiopathies | ||||
| Typical reactive ductules | + | + | − | − |
| Atypical reactive ductules | + | − | + | + |
| Ducts | + | + | − | − |
| Ductal plate malformations | ||||
| Typical reactive ductules | + | + | − | − |
| Atypical reactive ductules | + | − | + | + |
| Ducts | + | + | − | − |
On major ducts and typical reactive ductules scattered NCAM- and Bcl-2-positive cells can be seen occasionally. Staining key: strong (+, >50% ducts/ductules positive; weak (±), 10–50% ducts/ductules positive; absent (−), < 10% ducts/ductules positive.