Table 4.

Differential Expression of Maturation Markers in Fetal and Adult Diseased Liver

Markers	Fetal liver (10–16 gestational weeks)			Adult diseased liver
	Unduplicated ductal plate	Duplicated ductal plate	Hepatoblasts	Atypical ductules	Mature ducts	Periportal hepatocytes
CK717,34	−	−	−	+	+	+
CK817,34	+	+	+	+	+	+
CK1817,34	+	+	+	+	+	+
CK1917,34	+	+	+	+	+	±
HEA-125	+	+	+	+	+	+*
NCAM	+	Patchy	−	+	Rare	−
Bcl-2	+	Patchy	−	+	Rare	−
Ki-67	−	Rare	+	−	Rare	+
EMA	−	±	−	−	+	−
CD3367	+	+	−	ND	ND	ND
CD3467	+	+	−	ND	ND	ND
c-kit67	+	+	±	ND	ND	ND
OV-674–76	Patchy	Patchy	Scattered	Patchy	Patchy	+†

*HEA-125-positive periportal hepatocytes were observed mainly in parenchymal liver cirrhosis (see text).

^†OV-6-positive periportal hepatocytes were observed in PSC⁷⁴ and in biliary atresia and α1-anti-trypsin deficiency.⁷⁵