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BRCA2 Allelic Loss and K-ras Gene Mutation in Pancreatic Intraepithelial Neoplasia (PanIN)
| Patient | PanIN grade | LOH at BRCA2 | K-ras codon 12 |
|---|---|---|---|
| PX101 | 3 | Yes | GAT |
| 1 | No | GAT | |
| 1 | No | GAT | |
| 1 | No | GGT | |
| 1 | No | GGT | |
| 1 | No | GGT | |
| 1 | No | GGT | |
| PX66 | 1 | No | GAT |
| 1 | No | GGT | |
| 1 | No | GAT | |
| 1 | No | Not determined | |
| PX182 | 1 | No | GTT |
| 1 | No | GGT | |
| 1 | No | GAT |
The germline mutations of BRCA2 in cases PX101, PX66, and PX182 were 2481insT, 6174delT, and 6158insT, respectively. PX101 and PX66 had LOH of BRCA2 identified in the carcinoma samples.
