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. 2007 May;245(5):795–802. doi: 10.1097/01.sla.0000251513.59983.3b

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© 2007 Lippincott Williams & Wilkins, Inc.

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graphic file with name 19FF3.jpg — FIGURE 3. Preexposure to CpG-ODN followed by hemorrhagic shock enhanced intestinal permeability for horseradish peroxidase (HRP) via an IFN-γ-dependent route. Exposure to CpG-ODN increased permeability for HRP (5.5 ± 0.5 μg/mL, ^†P < 0.01) compared with control rats (1.0 ± 0.1 μg/mL). Hemorrhagic shock caused a substantial leakage of HRP (36 ± 3 μg/mL, **P < 0.01). Preexposure to CpG-ODN followed by hemorrhagic shock strongly aggravated intestinal permeability for HRP (60 ± 11 μg/mL, *P < 0.05). Administration of anti IFN-γ markedly reduced permeability for HRP in both control (^‡P < 0.05) and CpG-ODN-treated rats (^#P < 0.01) subjected to hemorrhagic shock: **,^†compared with control; *compared with control hemorrhagic shock; ^#compared with CpG-ODN shock; ‡compared with control hemorrhagic shock.