FIGURE 4. Mortality associated with early activation of the thrombomodulin-protein C pathway. A: Low plasma protein C levels on admission are associated with increased mortality. Protein C in quartiles. *P < 0.001 compared with protein C ≥102%. B: High plasma thrombomodulin levels on admission are associated with increased mortality. Thrombomodulin in quartiles. *P < 0.001 compared with thrombomodulin >42.2 ng/mL.