Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2007 Apr 30;7:39. doi: 10.1186/1471-213X-7-39

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2007 Pirity et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Retinal coloboma in Rybp+/- mouse embryo. (A-B) Hematoxylin and eosin- stained coronal sections of normal (A) and Rybp heterozygous null (B) eyes at E14.5. The neuroretina of the mutant eye is thickened and fails to close leading to the formation of coloboma (B; arrowhead). (C-D) Immunolocalization of Pax6 in wild type (C) and mutant (D) eyes. Pax6 is normally expressed in the ventral side of neuroretina. In the mutant eyes it shows broader expression in the retina and it is also more posteriorly positioned in the transition zone of the lens (C compare to D). (E-F) Immunolocalization of Pax2 in wild type (E) and mutant (F) eyes. L; lens, NR; neuroretina, ON; optic nerve, V; ventral, T; transitional zone. HE; hematoxylin and eosin. Magnifications: A-D(×320); E-F(×460)