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. 2007 Apr 30;7:39. doi: 10.1186/1471-213X-7-39

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Copyright © 2007 Pirity et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Progenitor cell fate is not changed in the mutant retinas of the Rybp heterozygous eyes. Wild type (A, C, E) and Rybp heterozygous null eyes exhibiting retinal coloboma (B, D, F) were stained with TUJ1 (A, B), NeuN (C, D) and Nestin (E, F) at E14.5. (A-B) TUJ1 staining, marking early neuronal cell types including ganglion cells of the retina, is comparable in the wildtype and mutant mice. (C-D) Similarly, NeuN, a postmitotic neural marker, shows no significant alteration in the mutant retinas. (E-F) The distribution of nestin, an intermediate filament marker for neural progenitor cells, is not affected in the mutant retinas. L; lens, NR; neuroretina, Magnifications: (×460)