Table 1.

Summary of ocular phenotypes

Ocular phenotype	Examined Mutant	No. with ocular phenotype/No. of examined mutants	Penetrance (%)
Coloboma (by E18.5)	Rybp heterozygous (+/-) mice	5/15	33
Coloboma, lens defects (By E14.5)	Chimeric mice Rybp-/- <->	6 exencephalic/19	32
	Rybp+/+	3 non exencephalic/19	16
Cataract (by 3 month)	ROSA26-Rybp/EGFP; αA-crystallin/Cre Tg/+ mice	44/75	59
Neovascularization (by 3 month)	ROSA26-Rybp/EGFP; β-Actin/Cre Tg/+ mice	30/87	35
Neovascularization (by 3 month)	ROSA26-Rybp/EGFP; β-Actin/Cre Tg/Tg mice	30/38	80
Coloboma, irregular retinal folds, anterior chamber defects (by P7)	ROSA26-Rybp/EGFP; β-Actin/Cre Tg/Tg mice	11/38	29