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. 2007 Jun;18(6):2179–2191. doi: 10.1091/mbc.E07-01-0074

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© 2007 by The American Society for Cell Biology

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Figure 5. — Severe phenotypes generated by RNAi-mediated depletion of Nopp140. (A) A salivary gland from a control +/da-GAL4 third instar larva. (B) Under identical magnification, the salivary gland from TCom.C4/da-GAL4 larva was about half the diameter of the normal gland. (C) DAPI-stained salivary glands from ±/da-GAL4 larvae showed chromatin distributed throughout much of the nucleus. (D) DAPI-stained salivary glands from TCom.C4/da-GAL4 larvae showed condensed chromatin and a greater density of nuclei per unit area, suggesting the cells were smaller than normal. (E and F) Melanotic tumors were observed in 5–10% of TCom.C4/da-GAL4 and PCom.K4/+; +/da-GAL4 larvae. (G) The melanotic tumors remained free of other tissues, and they were easily isolated by hand. (H) DAPI staining of the tumor showed a disorganized distribution of nuclei. Bars, 100 μm.