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Schematic models. (A) Functional cycle of Ssa1p ATPase. Different cofactors either stimulate ATPase activity of Ssa1p or stimulate ADP exchange. (B) Possible difference between [PSI+] and [URE3] prion propagation: because of the relatively shorter polymers, [PSI+] is more sensitive to Hsp104 action; instead, [URE3] is more sensitive to the Ssa1/Ydj1/Sse1 complex.
