Fig. 4.

The characteristic neurofibrillar pathologies of AD contain tau truncated at Asp⁴²¹. The CA1 hippocampal region from a patient with AD was analyzed by immunohistochemistry by using TauC3 (A) and Tau5 (B) mAbs. NFT and dystrophic neurites forming neuritic plaques (NP), two hallmark pathologic features of AD, are indicated. (Bars = 50 μm.) In C–E, laser-scanning confocal images of a single NFT from a patient with AD were stained with TauC3 (C) or Thiazin red (D); the latter is a marker for compact filaments (33). The merged image is shown in E. (Bar = 10 μm.)