Table 2. Reductions in gray-matter density common to both early and late groups, each compared with its own control group.
|
Coordinates
|
|||||||
|---|---|---|---|---|---|---|---|
| Region | Smoothing, mm | x | y | z | Corrected P value | Z score | Uncorrected P value |
| Left hippocampus | 4 | -30 | -12 | -22 | 3.89 | <0.001 | |
| Right hippocampus | 4 | 38 | -24 | -15 | 4.40 | <0.001 | |
| Right retrosplenial cortex | 4 | 12 | -60 | 14 | 0.002 | 5.85 | |
| Left putamen | 8 | -28 | 9 | -6 | 3.70 | <0.001 | |
| Right putamen | 8 | 32 | 3 | -8 | 3.63 | <0.001 | |
| Left caudate nucleus | 8 | -15 | 20 | -8 | 0.042 | 4.94 | |
| Right caudate nucleus | 8 | 14 | 20 | -6 | 3.38 | <0.001 | |
| Left thalamus | 8 | -12 | -21 | 4 | 3.87 | <0.001 | |
| Right thalamus | 8 | 8 | -22 | 9 | 4.03 | <0.001 | |
Unilateral conjunction analyses, MPRAGE (six early-onset patients, eight controls; four late-onset patients, eight controls). Corrected P values are included when they have reached significance at P < 0.05.