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The β1 subunit still restores Ca2+ sensitivity
to the TM channel after replacing the only intracellular negative charge on
the β1 subunit with a positive charge (E13K) and adding another adjacent
positive charge (T14R). (A) Representative single-channel currents
recorded from a TM channel in the presence of the doubly mutated β1
subunit. (B) Plots of Po vs.
for TM channels with the
doubly mutated β1 subunit.
