. 2003 Jul 29;100(17):10067–10072. doi: 10.1073/pnas.1633737100

Table 4.

Potency ratios for T₃ and KB-141 in vivo

Compound	ED₁₅ HR/ED₅₀ cholesterol	ED₁₅HR/ED₅ MV_o₂	ED₃₀ TSH/ED₅₀ cholesterol
T₃	30.8/20.6 = 1.5	30.8/21.5 = 1.4	6.7/21.6 = 0.3
KB-141	2,904/72.3 = 40.3 (27-fold vs. T₃)	2,904/232 = 12.5 (9-fold vs. T₃)	31.8/72.3 = 0.4 (1.3-fold vs. T₃)

All in vivo ED values are shown as nmol/kg per day. ED₁₅ HR is the dose causing 15% increase in HR; ED₅₀ cholesterol is the dose causing 50% reduction in cholesterol; ED₅ is the dose causing 5% increase in metabolic rate. ED₅ was chosen because it represents the potential therapeutic increase for antiobesity effects. ED₃₀ TSH is the dose causing a 30% reduction in TSH.