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Lineage of NP genes. Different colors indicate different lineages. A, ANP; B, BNP; C, CNP; C1-C4, CNP-1–CNP-4 of teleosts; CI and CII, CNP-I and CNP-II of the frog, respectively; Ebu, hagfish NP. Time of divergence is indicated in million years (Myr) ago according to Kumar and Hedges (28). The dotted line indicates unspecified timing of divergence. *, Medaka ANP has not been found.
