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. 2007 Mar 30;92(12):4304–4315. doi: 10.1529/biophysj.106.099606

FIGURE 1.

FIGURE 1

Outline of mitochondrial apoptosis regulatory network. We mainly focus on the roles of Bcl2 family proteins in regulating MOMP. Abbreviations of molecule names listed in Table 2 are used for clarity (e.g., Enabler (Ena), Activator (Act), inactive Bax (InBax), activated Bax (AcBax), etc.). Solid arrows denote reactions; dotted arrows describe subcellular translocation or upregulation; and those terminated by a bar denote interaction and inhibition. The dashed region indicates the core module of Bax activation.