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. 2007 Mar 30;92(12):4304–4315. doi: 10.1529/biophysj.106.099606

FIGURE 7.

FIGURE 7

The module of Bax activation shows bistabilities with the concentrations of (a) total Bax and (b) total Bcl2 as the bifurcation parameters. (a) Translocation of Bax is taken as the stimuli F (F2 = F3 = 0, F1 varies from 0 to 1). Actmito = 0.4 × 10−4 mM, Baxmito = 0 mM, Bcl2mito = 1 × 10−4 mM, and Baxcytosol = 2 × 10−4 mM are set as initial conditions. (b) Translocation of Bcl2 is taken as the stimuli F (F1 = F2 = 0, F3 varies from 0 to 1). Actmito = 0.3 × 10−4 mM, Baxmito = 2 × 10−4 mM, Bcl2mito = 0 mM, and Bcl2cytosol = 1 × 10−4 mM are set as initial condition.