TABLE 2.

Molecular table of CA modeling of mitochondrial apoptosis regulatory network

Abbreviations	Molecular descriptions	Weights	Velocities
Act	Activator	1	67
Bcl2	Bcl2	1	67
Ena	Enabler	1	67
ActBcl2	Heterodimer of Activator and Bcl2	2	50
EnaBcl2	Heterodimer of Enabler and Bcl2	2	50
InBax	Inactive Bax	1	67
AcBaxm	Activated Bax monomer/polymer (m represents the degree of polymerization of AcBax, e.g., m = 2 represent dimer of activated Bax, m can be omitted when m = 1)	m	0∼67
AcBaxBcl2	Heterodimer of Activated Bax and Bcl2	2	67
CC	Constitutive channel	20	9
AcBaxCC	Activated Bax and Constitutive Channel Complex	21	9
Bcl2CC	Bcl2 and Constitutive Channel Complex	21	9
Other	Other molecules which have no reactions with Bcl-2 family proteins	1	67

Molecular weights of various kinds of proteins are assigned to discriminate the moving abilities of different molecules. The weights of Act, Bcl2, Ena, InBax, and Other are set up to 1, and the weights of CC is assigned a value bigger than Act, Bcl2, Ena, InBax, and Other according to experimental observations by Verrier et al. (37). Through calculating we can get the weights of other molecules like heterodimers and homopolymers. Molecular velocities (V) are assumed to be in inverse proportion to molecular weights (W) and they are calculated from V = 100/(1 + W/A), where parameter A is used to regulate the inverse proportion relationship between W and V. We set A = 2 in our simulation and the values of relative molecules are listed in the velocities column of Table 2.