TABLE 1.
Intracellular ligands of rhodopsin considered in this study and their binding affinities to rhodopsin
| Peptide | Sequence | EC50 ± SE (μM) | Reference |
|---|---|---|---|
| Gtα(340-350) | IKENLKDCGLF-OH | 530 ± 90 | (9) |
| Peptide 2 | IKENLKDCGLW-OH | 540 ± 50 | (9) |
| Peptide 11 | IKENLKDCGL(2-Nal)-NH2 | 220 ± 70 | (9) |
| Peptide 14 | IKENLKDCGLF-NH2 | 320 ± 70 | (9) |
| Peptide 3 | IKENLKDCGLX* | 600 ± 90 | (10) |
| [R341, S347]- Gtα(340-350) | IRENLKDSGLF-OH | > 1000† | (42) |
*
X indicates a phenylethylamine derivative.
†
The EC50 value was measured on an acetylated peptide.