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Model of the B-cell/APC contact region. The cells are assumed to have a spherical shape, with the total vertical separation distance between the two surfaces at any point z = z1 + z2, with z1 and z2 given by Eq. 1. At the center of the contact zone (xo, yo), the vertical separation distance is at its minimum z = zo, whereas at the corners it is z = zmax. The 3 μm × 3 μm simulated area is large enough to include the entire zone where binding is possible.
