TABLE 2.
Parameters of the model
| Parameter | Description |
|---|---|
 |
Maximum BCR/Ag, BCR/Ag2 complex formation probability |
 |
Minimum BCR/Ag, BCR/Ag2 complex dissociation probability |
 |
Maximum LFA-1/ICAM-1 complex formation probability |
 |
Minimum LFA-1/ICAM-1 complex dissociation probability |
| B0 | Initial number of free BCR molecules |
| A0 | Initial number of free antigen molecules |
| L0 | Initial number of free LFA-1 molecules |
| I0 | Initial number of free ICAM-1 molecules |
| κBA | Stiffness of BCR/Ag bond |
| κLI | Stiffness of LFA-1/ICAM-1 bond |
| zeq(BA) | Equilibrium extracellular length of BCR/Ag complex |
| zeq(LI) | Equilibrium extracellular length of LFA-1/ICAM-1 complex |
| pdiff(B) | Probability of diffusion of a free BCR molecule |
| pdiff(A) | Probability of diffusion of a free antigen molecule |
| pdiff(L) | Probability of diffusion of a free LFA-1 molecule |
| pdiff(I) | Probability of diffusion of a free ICAM-1 molecule |
| pdiff(BA) | Probability of diffusion of a BCR/Ag, BCR/Ag2 complex |
| pdiff(LI) | Probability of diffusion of a LFA-1/ICAM-1 complex |
| M | Timescale of membrane deformation |
| γ | Membrane tension |
| β | Membrane bending rigidity |