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Schematic of two native-state proteins with coarse-grained surface regions of different average hydrophobic residue composition: patch (shaded) versus body (open). The size of the patch is defined by the angle α. The hydrophobicities of the patch Θp and body Θb are determined by Eq. 1. Since the dashed line connecting the protein centers passes through a patch region on each molecule, these two proteins are currently in a patch-patch alignment.
