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. 2007 May 25;3(5):e80. doi: 10.1371/journal.pgen.0030080

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© 2007 Lu et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A and B) Whole mount in situ hybridization shows abundant Nfia expression in the spinal cord (arrow) of E12.5 (A) and E13.5 (B) mouse embryos. The expression maximum (arrow) transits from rostral to caudal as development proceeds.

(C and D) Nfia expression is restricted to the floor plate and spinal ganglia at E11.5 (C), and to the ventral spinal cord at E13.5 (D).

(E and F) Spinal cord phenotype in Nfia E18.5 embryos. (E) The lumbar spinal cord central canal is nearly obliterated in wild-type embryos, whereas (F) shows persistent dilation of the lumbar spinal cord central canal (syringomyelia, arrow) in E18.5 Nfia ^−/− mutants.