Figure 5. Spectrum of Kidney Phenotypes in Nfia ^−/− Newborn Mice.

Whole mounts of dissected urinary tracts from newborn mice of the indicated genotype (A–F). Normal wild-type newborn kidney and renal histology (A and G); (B) rare Nfia ^+/− showing hydronephrosis (arrow); (C–F and H–K) Nfia ^−/− mutants showing bilateral renal agenesis (arrow in C), an elongated, partial duplex kidney with the abnormal cortical zone that demarcates the two poles shown with an arrow (D, H, and I), severely dysplastic kidney with irregular renal surface (arrow in E) and disorganized renal parenchyma (E and J), and nodular Nfia homozygous newborn kidney (F) with renal tubule cystic dilatation (K).