Figure 6. Nfia is Required for Normal Ureteral Development.

A Hoxb7-GFP transgenic reporter in the Nfia ^+/− and Nfia ^−/− backgrounds reveals ureteral defects in newborn mice.

(A–D) Wild-type and Nfia ^+/− newborns with megaureter (with extent of dilation indicated by two-headed arrow) (A, C) and partial ureteral duplication (arrow) in the mutant (C). Higher power views of boxed areas in (A) and (C), showing distortion of the mutant ureter at the UVJ (B and D); note that the vas deferens in the Nfia ^+/− male (C) is also GFP–positive.

(E and F) Abnormalities in Nfia ^−/− newborns include proximal flexion of the ureter (E) and dysplastic kidney (F).

k, kidney; t, testis; ur, ureter; UVJ, ureterovesical junction; v, vas deferens