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. 2007 May 25;3(5):e84. doi: 10.1371/journal.pgen.0030084

Figure 2. TOR Kinase Mediates Important Cellular Responses Implicated in Extended Longevity.

Figure 2

During periods of nutrient availability, TOR kinase is activated, leading to G1 progression, translation initiation, increased ribosome biogenesis, and a suppression of autophagy and the stress response.

When TOR is inactivated, either by DR or by the TOR inhibitor rapamycin, a cellular response is initiated that turns down protein translation and cell growth, and increases protein turnover and genes involved in the stress response. The conserved cellular regime that is the result of inactivated TOR kinase increases both replicative and chronological life span in yeast.