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Compounds 1 and 2 dock with the 2-5A-binding pocket of RNase L. Surface representations and side-chain interactions of p5′A2′p5′A2′p5′A (A and B), compound 1 (C and D), and compound 2 (E and F) to the ankyrin repeat region of human RNase L (PDB ID code 1WDY). Unique interactions in RNase L with either compound 1 or 2 are depicted in orange, whereas the common interactions with RNase L between 2-5A and compounds 1 or 2 are in green. esu, electrostatic unit.
