Interaction of CHOP-10 with C/EBPβ early in the
differentiation program. Nuclear extracts were prepared from 3T3-L1
preadipocytes before (day 0) and at 4 and 28 h after induction of
differentiation and subjected to immunoprecipitation with rabbit
anti-C/EBPβ N-terminal antibody by using protein A-Sepharose.
After three washes, supernatants and precipitates were separated by
SDS/PAGE and immunoblotted with mouse anti-C/EBPβ
C-terminal and mouse anti-CHOP-10 antibodies. Ab, antibody; Pi,
preimmune serum; KD, kDa; and Hrs, hours after induction of
differentiation.