Fig. 5.

Activity-dependent regulation of BDNF exon-specific mRNAs in rat hippocampus by kainic acid-induced seizures. The effect of kainate-induced seizures on the expression of different BDNF transcripts in the hippocampus of adult rat brain was examined. Adult rats were injected subcutaneously with kainic acid (8 mg per kg body weight) and sacrificed 1, 3, 6, 12, and 24 hr posttreatment. Total RNA was extracted, and semiquantitative RT-PCR was performed. Untreated rat hippocampus RNA was used as a control.