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. 2007 Jun 1;117(6):1514–1526. doi: 10.1172/JCI27095

Figure 8. Effects of human purified HCII supplementation on cuff-injured vascular remodeling in HCII+/– mice.

Figure 8

(A) Time course of plasma HCII activity in HCII+/– mice after an intraperitoneal injection of human purified HCII protein (h-HCII) (open circles) or a vehicle alone (filled circles). *P < 0.05. n = 4 in each group. (B) Representative histological findings of cuff-injured femoral arteries. Micrographs of cross sections of cuff-injured arteries stained with Elastica–van Gieson on day 28 in HCII+/+ mice treated with vehicle and in HCII+/– mice treated with vehicle alone or human purified HCII protein are shown. (C) Quantitative comparison of arterial intimal area, medial area, adventitial area, intima/media ratio, and adventitia/media ratio in cuff-injured HCII+/+ mice treated with vehicle (white bars) and HCII+/– mice treated with vehicle (black bars) or human purified HCII protein (gray bars). Values are expressed as mean ± SEM. *P < 0.05; **P < 0.01. n = 10 in each group.