Figure 1. Leukocyte-endothelium interactions in mouse peri-intestinal venules are increased by endogenous adiponectin deficiency.

(A) Leukocyte rolling flux in WT mice and Ad^–/– mice before and after treatment with human recombinant gAd (25 μg, s.c., twice daily for 10 days). (B) Leukocyte adhesion values under the same experimental conditions. Data are expressed as the mean ± SEM. Numbers at the base of the bars indicate the number of mice studied in each group. Pharmacologically active doses of gAd prevent abnormal leukocyte–endothelial cell interactions in the microcirculation in the face of chronic adiponectin deficiency.