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. 2007 Jun 1;117(6):1585–1594. doi: 10.1172/JCI30954

Figure 3. Histological kidney analyses.

Figure 3

(A) Gross kidney pathology. Kidneys of GneM712T/M712T mice showed hemorrhages but were normal in size and shape compared with kidneys of wild-type (Gne+/+) and heterozygous (GneM712T/+) littermates. (B) Representative H&E-stained sections of renal cortex (c) and medulla (m) showing tubular dilatations in GneM712T/M712T mice (arrows). Scale bars: 1,000 μm. (C) High magnification of collecting ducts, renal tubules, and urinary space, filled with rbc in GneM712T/M712T mice. Scale bars: 100 μm. (D) High magnification of glomeruli (g) with rbc infiltrated into the Bowman space in GneM712T/M712T mice. Scale bars: 100 μm. (E) Representative normal glomerulus (DICII filter, left panel) demonstrates abundance of Gne/Mnk protein inside the glomerular space upon immunolabeling with Gne/Mnk antibodies (FITC filter, right panel). Scale bars: 50 μm.