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. 2003 Jul 21;100(17):9837–9842. doi: 10.1073/pnas.1632156100

Fig. 1.

Fig. 1.

Alignments of AsnRS2 with archaeal AsnRS and AspRS. The alignment of 7 archaeal AsnRS (N),19 archaeal AspRS (D), and 7 AsnRS2 (2) is summarized. The sequences of the enzymes of P. abyssi (P_abyssi) and the consensus sequences encompassing the consensus motifs 1, 2, and 3 of class II aaRSs are shown. The motifs are schematized by black boxes located at the top or bottom of the sequences, and the invariant residues are indicated in white letters. The percentage homology is symbolized by shading: black and dark-gray shadings denote 100% and 80% of homology, and light-gray shading denotes conservation of the chemical nature in at least 80% of residues; dots symbolize lack of a residue in the detailed sequences and homology lower than 80% in the consensus sequences. Nomenclature of the consensus sequences is the following: a, aromatic; h, hydrophobic; – and +, negatively and positively charged; p, polar or small residues; ^ refers to a gap. Residues interacting with the aa (♦) or the adenylate (•) moiety of Asp∼AMP or with both (▪) in the 3D structure of the complex of Pyrococcus AspRS (22) are indicated.