Table 1. Results of the analysis of 105 genes using BEST.
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African American
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European American
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Shared SNPs
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|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | SNPs | Haplotypes | htSNPs | Ratio, % | Time, sec | Haplotypes | htSNPs | Ratio, % | Time, sec | Number | Ratio, % |
| ACE2 | 57 | 13 | 7 | 12 | 0 | 12 | 6 | 11 | 1 | 6 | 100 |
| BDKRB2 | 28 | 12 | 8 | 29 | 1 | 7 | 6 | 18 | 0 | 5 | 100 |
| BPI | 35 | 9 | 5 | 14 | 0 | 9 | 5 | 14 | 0 | 5 | 100 |
| CARD15 | 19 | 6 | 4 | 21 | 0 | 4 | 2 | 11 | 0 | 2 | 100 |
| CCR2 | 23 | 10 | 7 | 30 | 0 | 6 | 3 | 13 | 0 | 3 | 100 |
| CEBPB | 8 | 5 | 4 | 50 | 0 | 2 | 1 | 13 | 0 | 1 | 100 |
| CLCA1 | 103 | 3 | 2 | 2 | 0 | 3 | 2 | 2 | 0 | 2 | 100 |
| CRF | 21 | 10 | 6 | 24 | 0 | 8 | 4 | 19 | 0 | 4 | 100 |
| CRP | 18 | 10 | 6 | 33 | 0 | 9 | 6 | 33 | 0 | 6 | 100 |
| CSF2 | 14 | 11 | 6 | 43 | 0 | 8 | 4 | 29 | 0 | 4 | 100 |
| CSF3 | 12 | 6 | 5 | 42 | 0 | 2 | 1 | 8 | 0 | 1 | 100 |
| CSF3R | 41 | 14 | 6 | 15 | 0 | 11 | 5 | 12 | 5 | 5 | 100 |
| CYP4F2 | 79 | 10 | 5 | 6 | 23 | 8 | 4 | 5 | 1 | 4 | 100 |
| DCN | 66 | 3 | 2 | 3 | 0 | 3 | 2 | 3 | 0 | 2 | 100 |
| DEFB1 | 85 | 11 | 6 | 7 | 52 | 9 | 6 | 6 | 4 | 5 | 100 |
| F11 | 69 | 10 | 5 | 7 | 8 | 9 | 4 | 6 | 2 | 4 | 100 |
| F2 | 31 | 7 | 5 | 16 | 0 | 7 | 5 | 16 | 0 | 5 | 100 |
| F2R | 42 | 8 | 4 | 10 | 0 | 8 | 4 | 10 | 0 | 4 | 100 |
| F2RL1 | 29 | 7 | 4 | 14 | 0 | 7 | 4 | 14 | 0 | 4 | 100 |
| F2RL2 | 26 | 13 | 6 | 23 | 0 | 10 | 5 | 19 | 0 | 5 | 100 |
| F2RL3 | 23 | 9 | 7 | 30 | 0 | 7 | 5 | 22 | 0 | 5 | 100 |
| F3 | 22 | 10 | 6 | 27 | 0 | 7 | 4 | 18 | 0 | 4 | 100 |
| F7 | 20 | 8 | 5 | 25 | 0 | 5 | 3 | 15 | 0 | 3 | 100 |
| F9 | 51 | 12 | 7 | 14 | 0 | 10 | 4 | 8 | 1 | 3 | 75 |
| FGA | 8 | 7 | 5 | 63 | 0 | 2 | 1 | 13 | 0 | 1 | 100 |
| FGB | 29 | 6 | 6 | 17 | 0 | 3 | 2 | 7 | 0 | 2 | 100 |
| FGG | 8 | 6 | 4 | 50 | 0 | 3 | 2 | 25 | 0 | 2 | 100 |
| FGL2 | 10 | 6 | 5 | 50 | 0 | 3 | 2 | 20 | 0 | 2 | 100 |
| FSBP | 17 | 6 | 5 | 29 | 0 | 3 | 2 | 12 | 0 | 2 | 100 |
| GP1BA | 13 | 8 | 6 | 46 | 0 | 3 | 2 | 15 | 0 | 2 | 100 |
| IFNG | 8 | 7 | 5 | 63 | 0 | 3 | 2 | 25 | 0 | 2 | 100 |
| IGF2 | 13 | 11 | 7 | 54 | 0 | 7 | 4 | 31 | 0 | 4 | 100 |
| IL10 | 19 | 8 | 7 | 37 | 0 | 2 | 1 | 5 | 0 | 1 | 100 |
| IL11 | 23 | 12 | 6 | 26 | 0 | 10 | 5 | 22 | 0 | 5 | 100 |
| IL12A | 26 | 11 | 9 | 35 | 0 | 8 | 6 | 23 | 0 | 6 | 100 |
| IL12B | 25 | 8 | 6 | 24 | 0 | 4 | 3 | 12 | 0 | 3 | 100 |
| IL13 | 18 | 11 | 7 | 39 | 0 | 10 | 6 | 33 | 0 | 6 | 100 |
| IL17B | 16 | 5 | 4 | 25 | 0 | 3 | 2 | 13 | 0 | 2 | 100 |
| IL18 | 41 | 9 | 6 | 15 | 0 | 6 | 5 | 12 | 0 | 4 | 80 |
| IL18BP | 8 | 6 | 4 | 50 | 0 | 4 | 3 | 38 | 0 | 3 | 100 |
| IL19 | 19 | 7 | 5 | 26 | 0 | 4 | 3 | 16 | 0 | 3 | 100 |
| IL1B | 24 | 9 | 5 | 21 | 0 | 7 | 4 | 17 | 0 | 4 | 100 |
| IL1R2 | 97 | 7 | 4 | 4 | 0 | 5 | 3 | 3 | 0 | 3 | 100 |
| IL2 | 7 | 6 | 5 | 71 | 0 | 3 | 2 | 29 | 0 | 2 | 100 |
| IL20 | 9 | 11 | 6 | 56 | 0 | 8 | 4 | 44 | 0 | 4 | 100 |
| IL21R | 45 | 6 | 4 | 9 | 0 | 6 | 4 | 9 | 0 | 4 | 100 |
| IL22 | 21 | 9 | 4 | 19 | 1 | 6 | 3 | 14 | 0 | 3 | 100 |
| IL24 | 19 | 9 | 6 | 32 | 0 | 6 | 6 | 26 | 0 | 5 | 100 |
| IL3 | 7 | 8 | 6 | 71 | 0 | 5 | 3 | 43 | 0 | 3 | 100 |
| IL4 | 50 | 4 | 3 | 6 | 0 | 4 | 3 | 6 | 0 | 3 | 100 |
| IL5 | 5 | 7 | 5 | 100 | 0 | 5 | 3 | 60 | 0 | 3 | 100 |
| IL6 | 21 | 12 | 9 | 43 | 0 | 10 | 7 | 33 | 0 | 7 | 100 |
| IL8 | 7 | 7 | 5 | 71 | 0 | 5 | 3 | 43 | 0 | 3 | 100 |
| IL9 | 8 | 6 | 4 | 50 | 0 | 3 | 2 | 25 | 0 | 2 | 100 |
| IL9R | 51 | 5 | 3 | 6 | 0 | 5 | 3 | 6 | 0 | 3 | 100 |
| ITGA2 | 229 | 2 | 1 | 0 | 0 | 2 | 1 | 0 | 0 | 1 | 100 |
| JAK3 | 60 | 4 | 2 | 3 | 0 | 3 | 2 | 3 | 0 | 1 | 50 |
| KEL | 58 | 6 | 4 | 7 | 0 | 4 | 2 | 3 | 0 | 2 | 100 |
| KLK1 | 35 | 6 | 4 | 11 | 0 | 6 | 4 | 11 | 0 | 4 | 100 |
| LBP | 37 | 8 | 5 | 14 | 0 | 6 | 3 | 8 | 0 | 3 | 100 |
| LTB | 5 | 6 | 4 | 80 | 0 | 4 | 2 | 40 | 0 | 2 | 100 |
| LY64 | 40 | 10 | 6 | 15 | 0 | 9 | 5 | 13 | 0 | 5 | 100 |
| MC1R | 19 | 7 | 5 | 26 | 0 | 5 | 3 | 16 | 0 | 3 | 100 |
| MD-1 | 12 | 8 | 5 | 42 | 0 | 5 | 3 | 25 | 0 | 3 | 100 |
| MD-2 | 9 | 6 | 3 | 33 | 0 | 3 | 2 | 22 | 0 | 2 | 100 |
| MMP3 | 22 | 14 | 7 | 32 | 0 | 14 | 7 | 32 | 0 | 7 | 100 |
| NOS3 | 43 | 9 | 5 | 12 | 0 | 9 | 5 | 12 | 0 | 5 | 100 |
| PLAU | 18 | 7 | 6 | 33 | 0 | 4 | 3 | 17 | 0 | 3 | 100 |
| PLAUR | 65 | 6 | 3 | 6 | 0 | 5 | 3 | 5 | 0 | 3 | 100 |
| PLG | 106 | 9 | 5 | 5 | 1 | 9 | 5 | 5 | 1 | 5 | 100 |
| PON1 | 103 | 8 | 3 | 3 | 2 | 8 | 3 | 3 | 2 | 3 | 100 |
| PPARA | 64 | 3 | 2 | 3 | 0 | 2 | 1 | 2 | 0 | 1 | 100 |
| PPARG | 84 | 11 | 5 | 6 | 13 | 11 | 5 | 6 | 13 | 5 | 100 |
| PROC | 29 | 11 | 5 | 17 | 0 | 8 | 4 | 14 | 0 | 4 | 100 |
| PROZ | 35 | 7 | 4 | 11 | 0 | 6 | 3 | 9 | 0 | 3 | 100 |
| SCYA2 | 23 | 9 | 6 | 26 | 0 | 4 | 3 | 13 | 0 | 3 | 100 |
| SELE | 46 | 10 | 7 | 15 | 0 | 6 | 4 | 9 | 0 | 4 | 100 |
| SELP | 96 | 4 | 2 | 2 | 0 | 4 | 2 | 2 | 0 | 2 | 100 |
| SERPINA5 | 40 | 11 | 6 | 15 | 0 | 6 | 4 | 10 | 0 | 3 | 75 |
| SERPINC1 | 23 | 10 | 8 | 35 | 0 | 7 | 6 | 26 | 0 | 5 | 83 |
| SERPINE1 | 40 | 10 | 7 | 18 | 6 | 8 | 5 | 13 | 0 | 5 | 100 |
| SFTPB | 25 | 13 | 6 | 24 | 1 | 11 | 5 | 20 | 1 | 4 | 80 |
| SFTPD | 87 | 7 | 4 | 5 | 0 | 7 | 4 | 5 | 0 | 4 | 100 |
| SMP1 | 39 | 10 | 6 | 15 | 0 | 8 | 4 | 10 | 0 | 4 | 100 |
| STAT4 | 37 | 10 | 5 | 14 | 7 | 8 | 5 | 14 | 3 | 5 | 100 |
| STAT6 | 19 | 12 | 5 | 26 | 0 | 11 | 5 | 26 | 0 | 5 | 100 |
| TGFB3 | 37 | 8 | 5 | 14 | 0 | 6 | 4 | 11 | 0 | 4 | 100 |
| THBD | 6 | 7 | 4 | 67 | 0 | 3 | 2 | 33 | 0 | 2 | 100 |
| TLR1 | 30 | 10 | 8 | 27 | 0 | 7 | 6 | 20 | 0 | 6 | 100 |
| TLR10 | 44 | 6 | 4 | 9 | 0 | 4 | 3 | 7 | 0 | 3 | 100 |
| TLR2 | 9 | 8 | 5 | 56 | 0 | 4 | 2 | 22 | 0 | 2 | 100 |
| TLR3 | 11 | 7 | 6 | 45 | 0 | 2 | 1 | 9 | 0 | 1 | 100 |
| TLR4 | 14 | 6 | 6 | 36 | 0 | 4 | 3 | 21 | 0 | 3 | 100 |
| TLR5 | 54 | 13 | 7 | 13 | 0 | 10 | 5 | 9 | 2 | 5 | 100 |
| TLR7 | 59 | 14 | 6 | 8 | 0 | 13 | 5 | 8 | 0 | 5 | 100 |
| TLR8 | 43 | 14 | 7 | 16 | 0 | 11 | 6 | 14 | 0 | 5 | 83 |
| TNF | 6 | 8 | 5 | 83 | 0 | 4 | 2 | 33 | 0 | 2 | 100 |
| TNFAIP1 | 11 | 7 | 5 | 45 | 0 | 4 | 3 | 27 | 0 | 3 | 100 |
| TNFRSF1A | 29 | 12 | 6 | 21 | 4 | 11 | 6 | 21 | 3 | 6 | 100 |
| TOLLIP | 48 | 8 | 4 | 8 | 0 | 8 | 4 | 8 | 0 | 4 | 100 |
| TRAF6 | 34 | 12 | 7 | 21 | 0 | 10 | 6 | 18 | 0 | 6 | 100 |
| TRPV5 | 88 | 8 | 5 | 6 | 0 | 7 | 4 | 5 | 0 | 4 | 100 |
| VCAM1 | 40 | 7 | 4 | 10 | 0 | 7 | 4 | 10 | 0 | 4 | 100 |
| VEGF | 33 | 12 | 6 | 18 | 0 | 12 | 6 | 18 | 0 | 6 | 100 |
| VTN | 12 | 6 | 5 | 42 | 0 | 2 | 1 | 8 | 0 | 1 | 100 |
| Totals | 3,750 | 883 | 538 | 14 | 118 | 658 | 379 | 10 | 39 | 372 | 95 |
The first column lists the gene name and the second column reports the total number of SNPs in each gene. The following two blocks of four columns report the number of haplotypes (Haplotypes), the number of htSNPs (htSNPs), the proportion of htSNPs with respect to the total number of SNPs in the gene (Ratio), and the execution time in seconds (Time), for the African-American sample and the European-American sample. The last two columns report the absolute number (Number) and the proportion (Ratio) of htSNPs in the European-American sample also found in the African-American sample. For example, the first line reports that the haplotype set of gene ACE2 contains 57 SNPs, 13 haplotypes were identified in the African-American sample, 7 SNPs are sufficient to identify these haplotypes (12% of the original 57 SNPs), and it took <1 sec to identify them. The last two columns report that 6 tagging SNPs are shared between the African-American and the European-American samples, 100% of the tagging SNPs of the European-American sample.